Calixarenes, a member of macrocyclic compounds, have a ring
structure, are easily modified, and can be used to form molecular cavities of different sizes [0]. Calixarenes are mostly investigated for their
ability to be sensors for cation, anion, and neutral molecules and to
catalyze various reactions due to their basket appearance and different
spaces [0–0]. Besides, drug candidate properties and various biological
activities of these compounds have also entered the field of study in
recent years. A few of these are the investigation of the effects of DNA
cleavage or binding [0–0,00,00], antimicrobial [0–00] anti-tumor
[00–00], epigenetic [00], etc.
BODIPY compounds, which are 0,0-difluoro-0-borate-0a-azonia-0aaza-s-indacene, are fluorescent molecules in a neutral structure,
despite the negative and positive charge they carry. These compounds
have excellent photochemical and photophysical properties and are
generally used as biological imaging agents [00a], sensitizers for chemosensors [00b], solar cells [00], and optical materials [00]. However,
its effects on DNA have also been the subject of research and effective
results have been achieved [00–00].
Starting from the idea of synthesizing calixarene molecules with a
neutral structure and functional groups that can bind with DNA, in our
previous study we examined the effects of calixarene on DNA by synthesizing its derivatives with different heterocyclic structures (benzimidazole and benzothiazole) [00b]. Following this study, in which we
saw effective results, we conducted this study in which we investigated
how the activity on DNA would change by combining BODIPY compounds, which have become famous with studies on their biological