The first report of photosensitised 0
O0
intentionally applied in organic synthesis was by Schenck and
Ziegler in 0000, who used chlorophyll isolated from spinach
leaves to photosensitise singlet oxygen for the synthesis of
ascaridole, a natural product with application as a anthelmintic
agent [00]. Since 0000, singlet oxygen has been frequently
applied in the synthesis of natural products and pharmaceutically relevant agents [00]. Most notably it is used in the synthesis of artemisinin, an Nobel prize winning antimalarial drug
produced on a tonnes-per-year scale