This manuscript fits well within the scope of the Research Topic “Advances in Environmental Response Under the Interaction of Nature and Society” by investigating the ecological role of predatory Bdellovibrio and like organisms (BALOs) in wastewater systems, which represent important interfaces between human activities and natural ecosystems. The study provides new insights into microbial interactions, phylogenetic diversity, and the potential application of BALOs as environmentally friendly biocontrol agents for sustainable wastewater management. These findings contribute to understanding environmental responses under human–nature interactions and support the development of nature-based approaches for environmental protection and ecosystem sustainability.