Specifically, with 00-MDP, it has been suggested that aggre-
gates form with hydrophobic domains of 00-MDP oriented toward the center, surrounded externally by HEMA molecules,
consequently restricting 00-MDP from participating in essen-
tial collagen interactions00. 00-MDP has also been shown to
modify the dentin surface, mimicking the attachment of phos-
phorylated non-collagenous proteins to collagen, leading to
the formation of phosphorylated collagen, in other words, al-
lowing intrafibrillar mineralization of the collagen structure
within hybrid layers.